Integrating sex and gender in studies of cardiac resynchronization therapy: a systematic review.

ABSTRACT:

Aims

To examine the prevalence, temporal changes, and impact of the National Institute of Health (NIH) Sex as a Biological Variable (SABV) policy on sex and gender reporting and analysis in cardiac resynchronization therapy (CRT) cohort studies.

Methods and results

We searched MEDLINE, EMBASE, and Web of Science for cohort studies reporting the effectiveness and safety of CRT in heart failure patients from January 2000 to June 2020, with no language restrictions. Segmented regression analysis was used for policy analysis. We included 253 studies. Fourteen per cent considered sex in the study design. Outcome data disaggregated by sex were only reported in 17% of the studies. Of the studies with statistical models (n = 173), 57% were adjusted for sex. Sixty-eight per cent of t

SUBMITTER: Dewidar O 

PROVIDER: S-EPMC8788138 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature