Hundreds of Out-of-Frame Remodeled Gene Families in the Escherichia coli Pangenome.

ABSTRACT: All genomes include gene families with very limited taxonomic distributions that potentially represent new genes and innovations in protein-coding sequence, raising questions on the origins of such genes. Some of these genes are hypothesized to have formed de novo, from noncoding sequences, and recent work has begun to elucidate the processes by which de novo gene formation can occur. A special case of de novo gene formation, overprinting, describes the origin of new genes from noncoding alternative reading frames of existing open reading frames (ORFs). We argue that additionally, out-of-frame gene fission/fusion events of alternative reading frames of ORFs and out-of-frame lateral gene transfers could contribute to the origin of new gene families. To demonstrate this, we developed an orig

SUBMITTER: Watson AK 

PROVIDER: S-EPMC8788219 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature