Functional Constraints on Insect Immune System Components Govern Their Evolutionary Trajectories.

ABSTRACT: Roles of constraints in shaping evolutionary outcomes are often considered in the contexts of developmental biology and population genetics, in terms of capacities to generate new variants and how selection limits or promotes consequent phenotypic changes. Comparative genomics also recognizes the role of constraints, in terms of shaping evolution of gene and genome architectures, sequence evolutionary rates, and gene gains or losses, as well as on molecular phenotypes. Characterizing patterns of genomic change where putative functions and interactions of system components are relatively well described offers opportunities to explore whether genes with similar roles exhibit similar evolutionary trajectories. Using insect immunity as our test case system, we hypothesize that characterizing g

SUBMITTER: Ruzzante L 

PROVIDER: S-EPMC8788225 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature