Medication optimisation in severe mental illness (MEDIATE): protocol for a realist review.

ABSTRACT:

Introduction

Severe mental illness (SMI) is associated with significant morbidity and mortality. People living with SMI often receive complex medication regimens. Optimising these regimens can be challenging. Non-adherence is common and addressing it requires a collaborative approach to decision making. MEDIATE uses a realist approach with extensive engagement with experts-by-experience to make sense of the complexities and identify potential solutions.Realist research is used to unpack and explain complexity using programme theory/theories that contain causal explanations of outcomes, expressed as context-mechanism-outcome-configurations. The programme theory/theories will enable MEDIATE to address its aim of understanding what works, for whom, in what circumstances, to optimise m

SUBMITTER: Maidment I 

PROVIDER: S-EPMC8788310 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature