Nicotinamide Riboside-Conditioned Microbiota Deflects High-Fat Diet-Induced Weight Gain in Mice.

ABSTRACT: The gut microbiome plays an essential role in host energy homeostasis and influences the development of obesity and related conditions. Studies demonstrate that nicotinamide riboside (NR) supplementation for diet-induced obesity (DIO) reduces weight gain and increases energy expenditure in mice. NR is a vitamin B₃ derivative and an NAD⁺ precursor with potential for treating human diseases arising from mitochondrial degeneration, including obesity and type 2 diabetes. Gut bacteria produce vitamin B₃ in the colon and are capable of salvaging and metabolizing vitamin B₃ and its derivatives. However, it is unknown how dietary supplementation of NR alters the microbiome and if those alterations contribute to deflection of weight gain. In this study, w

SUBMITTER: Lozada-Fernandez VV 

PROVIDER: S-EPMC8788325 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature