Removal of off-resonance xenon gas artifacts in pulmonary gas-transfer MRI.

ABSTRACT:

Purpose

Hyperpolarized xenon (¹²⁹ Xe) gas-transfer imaging allows different components of pulmonary gas transfer-alveolar air space, lung interstitium/blood plasma (barrier), and red blood cells (RBCs)-to be assessed separately in a single breath. However, quantitative analysis is challenging because dissolved-phase ¹²⁹ Xe images are often contaminated by off-resonant gas-phase signal generated via imperfectly selective excitation. Although previous methods required additional data for gas-phase removal, the method reported here requires no/minimal sequence modifications/data acquisitions, allowing many previously acquired images to be corrected retroactively.

Methods

¹²⁹ Xe imaging was implemented at 3.0T via an interleaved three-dimensional

SUBMITTER: Willmering MM 

PROVIDER: S-EPMC8788625 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature