Citrullination in the pathology of inflammatory and autoimmune disorders: recent advances and future perspectives.

ABSTRACT: Numerous post-translational modifications (PTMs) govern the collective metabolism of a cell through altering the structure and functions of proteins. The action of the most prevalent PTMs, encompassing phosphorylation, methylation, acylations, ubiquitination and glycosylation is well documented. A less explored protein PTM, conversion of peptidylarginine to citrulline, is the subject of this review. The process of citrullination is catalysed by peptidylarginine deiminases (PADs), a family of conserved enzymes expressed in a variety of human tissues. Accumulating evidence suggest that citrullination plays a significant role in regulating cellular metabolism and gene expression by affecting a multitude of pathways and modulating the chromatin status. Here, we will discuss the biochemical nat

SUBMITTER: Ciesielski O 

PROVIDER: S-EPMC8788905 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature