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Neocortex saves energy by reducing coding precision during food scarcity.

ABSTRACT: Information processing is energetically expensive. In the mammalian brain, it is unclear how information coding and energy use are regulated during food scarcity. Using whole-cell recordings and two-photon imaging in layer 2/3 mouse visual cortex, we found that food restriction reduced AMPA receptor conductance, reducing synaptic ATP use by 29%. Neuronal excitability was nonetheless preserved by a compensatory increase in input resistance and a depolarized resting potential. Consequently, neurons spiked at similar rates as controls but spent less ATP on underlying excitatory currents. This energy-saving strategy had a cost because it amplified the variability of visually-evoked subthreshold responses, leading to a 32% broadening of orientation tuning and impaired fine visual discrimination. This reduction in coding precision was associated with reduced levels of the fat mass-regulated hormone leptin and was restored by exogenous leptin supplementation. Our findings reveal that metabolic state dynamically regulates the energy spent on coding precision in neocortex.

SUBMITTER: Padamsey Z

PROVIDER: S-EPMC8788933 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature

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Neocortex saves energy by reducing coding precision during food scarcity.

Padamsey Zahid Z Katsanevaki Danai D Dupuy Nathalie N Rochefort Nathalie L NL

Neuron 20211105 2

Information processing is energetically expensive. In the mammalian brain, it is unclear how information coding and energy use are regulated during food scarcity. Using whole-cell recordings and two-photon imaging in layer 2/3 mouse visual cortex, we found that food restriction reduced AMPA receptor conductance, reducing synaptic ATP use by 29%. Neuronal excitability was nonetheless preserved by a compensatory increase in input resistance and a depolarized resting potential. Consequently, neuron ...[more]

PMID: 34741806

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Dataset Information

Neocortex saves energy by reducing coding precision during food scarcity.

Publications

Neocortex saves energy by reducing coding precision during food scarcity.

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