Clinicopathologic, immunohistochemical, and ultrastructural features of histiocytic sarcoma in a chinchilla (Chinchilla lanigera).

ABSTRACT: A 9-year-old intact female chinchilla (Chinchilla lanigera) was presented to a referring veterinarian due to small, multiple cervical nodules that had been rapidly increasing in size and number. Cytology of the nodules revealed sheets of pleomorphic round cells that were morphologically most compatible with histiocytic sarcoma. Histologically, the nodules were fairly demarcated, partially infiltrative, densely cellular neoplasm, and was composed of pleomorphic large round cells arranged in sheets. Special stains for bacteria (Gram stain and Ziehl-Neelsen stain) and fungi (periodic acid-Schiff stain) were all negative. On immunohistochemistry, the neoplastic cells showed strong cytoplasmic positivity for Iba-1 and CD204, but were negative for CD3 and CD20. Transmission electron microscopy f

SUBMITTER: Enomoto K 

PROVIDER: S-EPMC8788969 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature