Contribution of the mutation rs8193069 in TLR4 to mastitis resistance and performance in Holstein cows in southern China.

ABSTRACT: Bovine mastitis has become increasingly important issues for farmers and consumers, leading to large economic losses in the dairy industry worldwide. Because treatment of mastitis is difficult and costly, improved mastitis resistance through selective breeding would be advantageous. The toll-like receptor 4 (TLR4) is an important player in recognising pathogens and activating immune responses. However, its roles in mastitis occurrence and the underlying molecular mechanisms are unclear. In this study, a single nucleotide polymorphism, rs8193069 (T → C) in TLR4 gene was detected in a Holstein cow resource population in southern China. Association analysis with 5-year production traits, haematology, and biochemistry parameters revealed that individuals with genotype CC had significantly lowe

SUBMITTER: Chen H 

PROVIDER: S-EPMC8788991 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature