Prediction of lithium treatment response in bipolar depression using 5-HTT and 5-HT_1A PET.

ABSTRACT:

Background

Lithium, one of the few effective treatments for bipolar depression (BPD), has been hypothesized to work by enhancing serotonergic transmission. Despite preclinical evidence, it is unknown whether lithium acts via the serotonergic system. Here we examined the potential of serotonin transporter (5-HTT) or serotonin 1A receptor (5-HT_1A) pre-treatment binding to predict lithium treatment response and remission. We hypothesized that lower pre-treatment 5-HTT and higher pre-treatment 5-HT_1A binding would predict better clinical response. Additional analyses investigated group differences between BPD and healthy controls and the relationship between change in binding pre- to post-treatment and clinical response. Twenty-seven medication-free patients with

SUBMITTER: Ananth M 

PROVIDER: S-EPMC8789023 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature