Metabolically healthy obesity, transition to unhealthy phenotypes, and type 2 diabetes in 0.5 million Chinese adults: the China Kadoorie Biobank.

ABSTRACT:

Objectives

To prospectively assess the association of metabolic health status and its transition with incident diabetes risk across BMI categories.

Design

Cohort study based on the China Kadoorie Biobank (CKB).

Methods

The CKB study enrolled 512 715 adults aged 30-79 years from ten diverse areas in China during 2004-2008. After exclusion, 432 763 participants were cross-classified by BMI categories and the metabolic status was followed up for incident diabetes disease. The changes in BMI and metabolic health status were defined from baseline to the second resurvey.

Results

Type 2 diabetes risk is higher for metabolically healthy obese (MHO) subjects than metabolically healthy normal weight (MHN) individuals (HR: 3.97, 95% CI: 3.64-3.66), and it is highest for t

SUBMITTER: Song Z 

PROVIDER: S-EPMC8789025 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature