Intermolecular Interactions Drive Protein Adaptive and Coadaptive Evolution at Both Species and Population Levels.

ABSTRACT: Proteins are the building blocks for almost all the functions in cells. Understanding the molecular evolution of proteins and the forces that shape protein evolution is essential in understanding the basis of function and evolution. Previous studies have shown that adaptation frequently occurs at the protein surface, such as in genes involved in host-pathogen interactions. However, it remains unclear whether adaptive sites are distributed randomly or at regions associated with particular structural or functional characteristics across the genome, since many proteins lack structural or functional annotations. Here, we seek to tackle this question by combining large-scale bioinformatic prediction, structural analysis, phylogenetic inference, and population genomic analysis of Drosophila prot

SUBMITTER: Peng J 

PROVIDER: S-EPMC8789070 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature