Dynamic platelet function: A novel biomarker in inflammatory arthritis?

ABSTRACT:

Background

Patients with inflammatory arthritis die prematurely of cardiovascular disease. Inflammation activates platelets. Since treatment of inflammatory arthritis is associated with reduced mortality, and decreased platelet reactivity reduces cardiovascular events, we hypothesised that platelet reactivity as measured by dynamic platelet function (DPF) would be increased in patients with inflammatory arthritis and that reactivity could be reduced with therapeutic intervention.

Objectives

To characterise platelet function using a validated physiological assay in patients with inflammatory arthritis before and after disease improvement.

Methods

22 patients were recruited and treated as per local protocol. DPF was measured at baseline and after clinical improvement. V

SUBMITTER: Nic An Riogh E 

PROVIDER: S-EPMC8789097 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature