Long-term glycemic variability and the risk of mortality in diabetic patients receiving peritoneal dialysis.

ABSTRACT:

Background

The large amount of glucose in the dialysate used in peritoneal dialysis (PD) likely affects the glycemic control. The aim of this study was to investigate the association between HbA1c variability, as a measure of long-term glycemic variability, and the risk of all-cause mortality in diabetic patients with PD.

Methods

325 patients with diabetes and ESRD were followed (2008-2018) in the Swedish Renal Registry. Patients were separated in seven groups according to level of HbA1c variability. The group with the lowest variability was denoted the reference. The ratio of the standard deviation (SD) to the mean of HbA1c, HbA1c (SD)/HbA1c (mean), i.e. the coefficient of variation (CV), was defined as HbA1c variability. Hazard ratios (HR) and 95% confidence intervals (CI)

SUBMITTER: Afghahi H 

PROVIDER: S-EPMC8789125 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature