The Occurrence of Malignancy in Trypanosoma brucei brucei by Rapid Passage in Mice.

ABSTRACT: Pleomorphic Trypanosoma brucei are best known for their tightly controlled cell growth and developmental program, which ensures their transmissibility and host fitness between the mammalian host and insect vector. However, after long-term adaptation in the laboratory or by natural evolution, monomorphic parasites can be derived. The origin of these monomorphic forms is currently unclear. Here, we produced a series of monomorphic trypanosome stocks by artificially syringe-passage in mice, creating snapshots of the transition from pleomorphism to monomorphism. We then compared these artificial monomorphic trypanosomes, alongside several naturally monomorphic T. evansi and T. equiperdum strains, with the pleomorphic T. brucei. In addition to failing to generate stu

SUBMITTER: Cai XL 

PROVIDER: S-EPMC8789148 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature