CKMT1A is a novel potential prognostic biomarker in patients with endometrial cancer.

ABSTRACT:

Purpose

The International Federation of Gynecology and Obstetrics (FIGO) stage remains the standard staging system for the assessment of endometrial cancer (EC) prognosis. Thus, we aim to identify the significant genes or biomarkers associated with the stage of endometrial cancer, which may also help reveal the mechanism of EC progression and assess the prognosis of patients with EC.

Materials and methods

We compared the mRNA expression levels of EC patients with stages I and II as well as stages III and IV in the Cancer Genome Atlas (TCGA) database. The differentially expressed genes (DEGs) of EC patients at different stages were selected by volcano plot and Venn analysis. Gene Ontology (GO) and Pathways were applied to analyze the identified genes. Protein protein interact

SUBMITTER: Wang Y 

PROVIDER: S-EPMC8789190 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature