Loss of Timeless Underlies an Evolutionary Transition within the Circadian Clock.

ABSTRACT: Most organisms possess time-keeping devices called circadian clocks. At the molecular level, circadian clocks consist of transcription-translation feedback loops (TTFLs). Although some components of the negative TTFL are conserved across the animals, important differences exist between typical models, such as mouse and the fruit fly. In Drosophila, the key components are PERIOD (PER) and TIMELESS (TIM-d) proteins, whereas the mammalian clock relies on PER and CRYPTOCHROME (CRY-m). Importantly, how the clock has maintained functionality during evolutionary transitions between different states remains elusive. Therefore, we systematically described the circadian clock gene setup in major bilaterian lineages and identified marked lineage-specific differences in their clock constitution. Then

SUBMITTER: Kotwica-Rolinska J 

PROVIDER: S-EPMC8789273 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature