Ontology highlight
ABSTRACT:
SUBMITTER: Shibuya Y
PROVIDER: S-EPMC8789286 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Shibuya Yoichiro Y Hokugo Akishige A Okawa Hiroko H Kondo Takeru T Khalil Daniel D Wang Lixin L Roca Yvonne Y Clements Adam A Sasaki Hodaka H Berry Ella E Nishimura Ichiro I Jarrahy Reza R
eLife 20220118
Attempts to minimize scarring remain among the most difficult challenges facing surgeons, despite the use of optimal wound closure techniques. Previously, we reported improved healing of dermal excisional wounds in circadian clock neuronal PAS domain 2 (<i>Npas2</i>)-null mice. In this study, we performed high-throughput drug screening to identify a compound that downregulates <i>Npas2</i> activity. The hit compound (Dwn1) suppressed circadian <i>Npas2</i> expression, increased murine dermal fib ...[more]