Disease consequences of higher adiposity uncoupled from its adverse metabolic effects using Mendelian randomisation.

ABSTRACT:

Background

Some individuals living with obesity may be relatively metabolically healthy, whilst others suffer from multiple conditions that may be linked to adverse metabolic effects or other factors. The extent to which the adverse metabolic component of obesity contributes to disease compared to the non-metabolic components is often uncertain. We aimed to use Mendelian randomisation (MR) and specific genetic variants to separately test the causal roles of higher adiposity with and without its adverse metabolic effects on diseases.

Methods

We selected 37 chronic diseases associated with obesity and genetic variants associated with different aspects of excess weight. These genetic variants included those associated with metabolically 'favourable adiposity' (FA) and 'unfavour

SUBMITTER: Martin S 

PROVIDER: S-EPMC8789289 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature