Urinary metabolic biomarkers of diet quality in European children are associated with metabolic health.

ABSTRACT: Urinary metabolic profiling is a promising powerful tool to reflect dietary intake and can help understand metabolic alterations in response to diet quality. Here, we used ¹H NMR spectroscopy in a multicountry study in European children (1147 children from 6 different cohorts) and identified a common panel of 4 urinary metabolites (hippurate, N-methylnicotinic acid, urea, and sucrose) that was predictive of Mediterranean diet adherence (KIDMED) and ultra-processed food consumption and also had higher capacity in discriminating children's diet quality than that of established sociodemographic determinants. Further, we showed that the identified metabolite panel also reflected the associations of these diet quality indicators with C-peptide, a stable and accurate marker of

SUBMITTER: Stratakis N 

PROVIDER: S-EPMC8789316 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature