Multidimensional predictors of negative symptoms in antipsychotic-naive first-episode psychosis.

ABSTRACT:

Background

Despite a large body of schizophrenia research, we still have no reliable predictors to guide treatment from illness onset. The present study aimed to identify baseline clinical or neurobiological factors - including peripheral brain-derived neurotrophic factor (BDNF) levels and amygdala or hippocampal relative volumes - that could predict negative symptomatology and persistent negative symptoms in first-episode psychosis after 1 year of follow-up.

Methods

We recruited 50 drug-naive patients with first-episode psychosis and 50 age- and sex-matched healthy controls to study brain volumes. We performed univariate and multiple and logistic regression analyses to determine the association between baseline clinical and neurobiological variables, score on the PANSS nega

SUBMITTER: Toll A 

PROVIDER: S-EPMC8789336 | biostudies-literature | 2022 Jan-Feb

REPOSITORIES: biostudies-literature