Ontology highlight
ABSTRACT:
SUBMITTER: Zarhin D
PROVIDER: S-EPMC8789564 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Zarhin Daniel D Atsmon Refaela R Ruggiero Antonella A Baeloha Halit H Shoob Shiri S Scharf Oded O Heim Leore R LR Buchbinder Nadav N Shinikamin Ortal O Shapira Ilana I Styr Boaz B Braun Gabriella G Harel Michal M Sheinin Anton A Geva Nitzan N Sela Yaniv Y Saito Takashi T Saido Takaomi T Geiger Tamar T Nir Yuval Y Ziv Yaniv Y Slutsky Inna I
Cell reports 20220101 3
Dysregulated homeostasis of neural activity has been hypothesized to drive Alzheimer's disease (AD) pathogenesis. AD begins with a decades-long presymptomatic phase, but whether homeostatic mechanisms already begin failing during this silent phase is unknown. We show that before the onset of memory decline and sleep disturbances, familial AD (fAD) model mice display no deficits in CA1 mean firing rate (MFR) during active wakefulness. However, homeostatic down-regulation of CA1 MFR is disrupted d ...[more]