Vagus Nerve Stimulation Reduces Indomethacin-Induced Small Bowel Inflammation.

ABSTRACT: Crohn's disease is a chronic, idiopathic condition characterized by intestinal inflammation and debilitating gastrointestinal symptomatology. Previous studies of inflammatory bowel disease (IBD), primarily in colitis, have shown reduced inflammation after electrical or pharmacological activation of the vagus nerve, but the scope and kinetics of this effect are incompletely understood. To investigate this, we studied the effect of electrical vagus nerve stimulation (VNS) in a rat model of indomethacin-induced small intestinal inflammation. 1 min of VNS significantly reduced small bowel total inflammatory lesion area [(mean ± SEM) sham: 124 ± 14 mm², VNS: 62 ± 14 mm², p = 0.002], intestinal peroxidation and chlorination rates, and intestinal and systemic pro-infl

SUBMITTER: Caravaca AS 

PROVIDER: S-EPMC8789651 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature