[¹⁸F] Sodium Fluoride Dose Reduction Enabled by Digital Photon Counting PET/CT for Evaluation of Osteoblastic Activity.

ABSTRACT: The aim of the study was to assess the quality and reproducibility of reducing the injected [¹⁸F] sodium fluoride ([¹⁸F]NaF) dose while maintaining diagnostic imaging quality in bone imaging in a preclinical skeletal model using digital photon counting PET (dPET) detector technology. Beagles (n = 9) were administered three different [¹⁸F]NaF doses: 111 MBq (n = 5), 20 MBq (n = 5), and 1.9 MBq (n = 9). Imaging started ≃45 min post-injection for ≃30 min total acquisition time. Images were reconstructed using Time-of-Flight, ultra-high definition (voxel size of 1 × 1 × 1 mm³), with 3 iterations and 3 subsets. Point spread function was modeled and Gaussian filtering was applied. Skeleton qualitative and quantitative molecu

SUBMITTER: Menendez MI 

PROVIDER: S-EPMC8789749 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature