Ozone exposure upregulates the expression of host susceptibility protein TMPRSS2 to SARS-CoV-2.

ABSTRACT: SARS-CoV-2, a novel coronavirus and an etiologic agent for the current global health emergency, causes acute infection of the respiratory tract leading to severe disease and significant mortality. Ever since the start of SARS-CoV-2, also known as the COVID-19 pandemic, countless uncertainties have been revolving around the pathogenesis and epidemiology of the SARS-CoV-2 infection. While air pollution has been shown to be strongly correlated to increased SARS-CoV-2 morbidity and mortality, whether environmental pollutants such as ground-level ozone affects the susceptibility of individuals to SARS-CoV-2 is not yet established. To investigate the impact of ozone inhalation on the expression levels of signatures associated with host susceptibility to SARS-CoV-2, we analyzed lung tissues colle

SUBMITTER: Vo T 

PROVIDER: S-EPMC8789794 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature