Early downregulation of hsa-miR-144-3p in serum from drug-naive Parkinson's disease patients.

ABSTRACT: Advanced age represents one of the major risk factors for Parkinson's Disease. Recent biomedical studies posit a role for microRNAs, also known to be remodelled during ageing. However, the relationship between microRNA remodelling and ageing in Parkinson's Disease, has not been fully elucidated. Therefore, the aim of the present study is to unravel the relevance of microRNAs as biomarkers of Parkinson's Disease within the ageing framework. We employed Next Generation Sequencing to profile serum microRNAs from samples informative for Parkinson's Disease (recently diagnosed, drug-naïve) and healthy ageing (centenarians) plus healthy controls, age-matched with Parkinson's Disease patients. Potential microRNA candidates markers, emerging from the combination of differential expression and netw

SUBMITTER: Zago E 

PROVIDER: S-EPMC8789812 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature