Dosimetry of heavy ion exposure to human cells using nanoscopic imaging of double strand break repair protein clusters.

ABSTRACT: The human body is constantly exposed to ionizing radiation of different qualities. Especially the exposure to high-LET (linear energy transfer) particles increases due to new tumor therapy methods using e.g. carbon ions. Furthermore, upon radiation accidents, a mixture of radiation of different quality is adding up to human radiation exposure. Finally, long-term space missions such as the mission to mars pose great challenges to the dose assessment an astronaut was exposed to. Currently, DSB counting using γH2AX foci is used as an exact dosimetric measure for individuals. Due to the size of the γH2AX IRIF of ~ 0.6 µm, it is only possible to count DSB when they are separated by this distance. For high-LET particle exposure, the distance of the DSB is too small to be separated and the dose w

SUBMITTER: Reindl J 

PROVIDER: S-EPMC8789836 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature