Protective effects of gallocatechin gallate against ultraviolet B induced skin damages in hairless mice.

ABSTRACT: Epigallocatechin gallate (EGCG) has the effect to protect skin from ultraviolet B (UVB) induced damages, but it is unstable under ambient conditions, being susceptible to become brown in color. Gallocatechin gallate (GCG), an epimer counterpart of EGCG, is more stable chemically than EGCG. The potential effects of GCG against UVB-induced skin damages has not been available. The objective of this study was to investigate the protective effects of GCG against UVB-induced skin photodamages. GCG was topically applied on the skin of hairless mice at three dosage levels (LL, 12.5 mg/mL; ML 25 mg/mL; HL, 50 mg/mL), with EGCG and a commercially available baby sunscreen lotion SPF50 PA⁺⁺⁺ as control. The mice were then irradiated by UVB (fluence rate 1.7 µmol/m² s) for 45 min.

SUBMITTER: Sheng YY 

PROVIDER: S-EPMC8789851 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature