Receptor-targeted nanoparticles modulate cannabinoid anticancer activity through delayed cell internalization.

ABSTRACT: Δ⁹-tetrahydrocannabinol (Δ⁹-THC) is known for its antitumor activity and palliative effects. However, its unfavorable physicochemical and biopharmaceutical properties, including low bioavailability, psychotropic side effects and resistance mechanisms associated to dosing make mandatory the development of successful drug delivery systems. In this work, transferring (Tf) surface-modified Δ^9-THC-loaded poly(lactide-co-glycolic) nanoparticles (Tf-THC-PLGA NPs) were proposed and evaluated as novel THC-based anticancer therapy. Furthermore, in order to assess the interaction of both the nanocarrier and the loaded drug with cancer cells, a double-fluorescent strategy was applied, including the chemical conjugation of a dye to the nanoparticle polymer along with th

SUBMITTER: Duran-Lobato M 

PROVIDER: S-EPMC8789857 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature