Genetic risk, adherence to a healthy lifestyle, and cognitive decline in African Americans and European Americans.

ABSTRACT:

Introduction

We investigated the role of genetic risk and adherence to lifestyle factors on cognitive decline in African Americans and European Americans.

Methods

Using data from the Chicago Health and Aging Project (1993-2012; n = 3874), we defined the genetic risk based on presence of apolipoprotein E (APOE) ε4$\varepsilon 4$ allele and determined a healthy lifestyle using a scoring of five factors: non-smoking, exercising, being cognitively active, having a high-quality diet, and limiting alcohol use. We used linear mixed-effects models to estimate cognitive decline by genetic risk and lifestyle score.

Results

APOE  ε4$\varepsilon 4$ allele was associated with faster cognitive decline in both races. However, within APOE  ε4$\varepsilon 4$ carriers, adherence to a h

SUBMITTER: Dhana K 

PROVIDER: S-EPMC8789942 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature