Energy dissipation of osteopontin at a HAp mineral interface: Implications for bone biomechanics.

ABSTRACT: Osteopontin (OPN) is a one of the most abundant non-collagenous proteins in the bone's organic matrix. OPN is responsible for mediating bonding at mineral interfaces in the extrafibrillar space and recent evidence shows that it is a major contributor to bone's fracture resistance. While several experimental studies have identified an important role for calcium ions in mediating energy dissipation in OPN protein networks, the underlying molecular mechanisms remain largely unknown. In the current study, the role of calcium ions on energy dissipation at OPN interface with hydroxyapatite (HAp) as the main bone mineral was investigated. For the first time, the three-dimensional structure of OPN proteins were predicted, and it was found that calcium ions greatly influenced the final protein conf

SUBMITTER: Tavakol M 

PROVIDER: S-EPMC8790188 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature