Cell-cell adhesion impacts epithelia response to substrate stiffness: Morphology and gene expression.

ABSTRACT: Monolayer epithelial cells interact constantly with the substrate they reside on and their surrounding neighbors. As such, the properties of epithelial cells are profoundly governed by the mechanical and molecular cues that arise from both the substrate and contiguous cell neighbors. Although both cell-substrate and cell-cell interactions have been studied individually, these results are difficult to apply to native confluent epithelia, in which both jointly regulate the cell phenotype. Specifically, it remains poorly understood about the intertwined contributions from intercellular adhesion and substrate stiffness on cell morphology and gene expression, two essential microenvironment properties. Here, by adjusting the substrate modulus and altering the intercellular adhesion within conflu

SUBMITTER: Choi D 

PROVIDER: S-EPMC8790207 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature