On the design principles of metabolic flux sensing.
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ABSTRACT:
SUBMITTER: Euler C
PROVIDER: S-EPMC8790210 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Publications
On the design principles of metabolic flux sensing.
Euler Christian C Mahadevan Radhakrishnan R
Biophysical journal 20211222 2
Metabolism is precisely coordinated, with the goal of balancing fluxes to maintain robust growth. However, coordinating fluxes requires information about rates, which can only be inferred through concentrations. While flux-sensitive metabolites have been reported, the design principles underlying such sensing have not been clearly elucidated. Here we use kinetic modeling to show that substrate concentrations of thermodynamically constrained reactions reflect upstream flux and therefore carry inf ...[more]
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