Ontology highlight
ABSTRACT:
SUBMITTER: Lay CS
PROVIDER: S-EPMC8790524 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Lay Charles S CS Bridges Angela A Goulding Joelle J Briddon Stephen J SJ Soloviev Zoja Z Craggs Peter D PD Hill Stephen J SJ
Cell chemical biology 20210525 1
Interleukin-23 (IL-23) is a pro-inflammatory cytokine involved in the host defense against pathogens but is also implicated in the development of several autoimmune disorders. The IL-23 receptor has become a key target for drug discovery, but the exact mechanism of the receptor ligand interaction remains poorly understood. In this study the affinities of IL-23 for its individual receptor components (IL23R and IL12Rβ1) and the heteromeric complex formed between them have been measured in living c ...[more]