Prognostic and Predictive Value of BGN in Colon Cancer Outcomes and Response to Immunotherapy.

ABSTRACT:

Background

Colon cancer is one of the most frequent malignancies and causes high mortality worldwide. Exploring the tumor-immune interactions in the tumor microenvironment and identifying new prognostic and therapeutic biomarkers will assist in decoding the novel mechanism of tumor immunotherapy. BGN is a typical extracellular matrix protein that was previously validated as a signaling molecule regulating multiple processes of tumorigenesis. However, its role in tumor immunity requires further investigation.

Methods

The differentially expressed genes in three GEO datasets were analyzed, and BGN was identified as the target gene by intersection analysis of PPIs. The relevance between clinical outcomes and BGN expression levels was evaluated using data from the GEO database, T

SUBMITTER: He ZX 

PROVIDER: S-EPMC8790701 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature