Ontology highlight
ABSTRACT:
SUBMITTER: Tao Y
PROVIDER: S-EPMC8790745 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Tao Yining Y Yan Chenxu C Li Dan D Dai Jianfeng J Cheng Yingsheng Y Li Hui H Zhu Wei-Hong WH Guo Zhiqian Z
JACS Au 20220110 1
Pancreatic ductal adenocarcinoma (PDAC), as one of the most malignant tumors with dense desmoplastic stroma, forms a specific matrix barrier to hinder effective diagnosis and therapy. To date, a paramount challenge is in the search for intelligent nanotheranostics for such hypopermeable tumors, especially in breaking the PDAC-specific physical barrier. The unpredictable <i>in vivo</i> behaviors of nanotheranostics, that is, real-time tracking where, when, and how they cross the physical barriers ...[more]