Pregnancy loss and risk of cardiovascular disease: the Nurses' Health Study II.

ABSTRACT:

Aims

The aim of this study was to explore the association of pregnancy loss (PL) with the incidence of cardiovascular disease (CVD) and examine the extent to which this relation is mediated by subsequent metabolic disorders.

Methods and results

We followed 95 465 ever-gravid women participating in the Nurses' Health Study II between 1993 and 2017. Cox proportional hazards models were used to estimate the hazard ratios (HRs) of CVD, including coronary heart disease (CHD), and stroke, according to the occurrence of PL. A mediation analysis was conducted to explore the intermediating effect of subsequent type 2 diabetes, hypertension, or hypercholesterolaemia. During 2 205 392 person-years of follow-up (mean 23.10 years), 2225 (2.3%) incident CVD cases were documented. After ad

SUBMITTER: Wang YX 

PROVIDER: S-EPMC8790762 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature