Ontology highlight
ABSTRACT:
SUBMITTER: Plais L
PROVIDER: S-EPMC8790773 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Plais Louise L Lessing Alice A Keller Michelle M Martinelli Adriano A Oehler Sebastian S Bassi Gabriele G Neri Dario D Scheuermann Jörg J
Chemical science 20220111 4
DNA-encoded chemical libraries (DELs) are useful tools for the discovery of small molecule ligands to protein targets of pharmaceutical interest. Compared with single-pharmacophore DELs, dual-pharmacophore DELs simultaneously display two chemical moieties on both DNA strands, and allow for the construction of highly diverse and pure libraries, with a potential for targeting larger protein surfaces. Although methods for the encoding of simple, fragment-like dual-display libraries have been establ ...[more]