Capsule-like DNA Hydrogels with Patterns Formed by Lateral Phase Separation of DNA Nanostructures.

ABSTRACT: Phase separation is a key phenomenon in artificial cell construction. Recent studies have shown that the liquid-liquid phase separation of designed-DNA nanostructures induces the formation of liquid-like condensates that eventually become hydrogels by lowering the solution temperature. As a compartmental capsule is an essential artificial cell structure, many studies have focused on the lateral phase separation of artificial lipid vesicles. However, controlling phase separation using a molecular design approach remains challenging. Here, we present the lateral liquid-liquid phase separation of DNA nanostructures that leads to the formation of phase-separated capsule-like hydrogels. We designed three types of DNA nanostructures (two orthogonal and a linker nanostructure) that were adsorbed

SUBMITTER: Sato Y 

PROVIDER: S-EPMC8790810 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature