High complement protein C1q levels in pulmonary fibrosis and non-small cell lung cancer associated with poor prognosis.

ABSTRACT:

Background

Idiopathic pulmonary fibrosis (IPF) is the most common type of interstitial pneumonia. Lung cancer, mainly non-small cell lung cancer (NSCLC), is a complication of idiopathic pulmonary fibrosis. IPF is also an independent risk factor of lung cancer. Some studies have shown that the complement system can promote the progression of interstitial pulmonary fibrosis. In addition, C1q has also demonstrated to exert a tumor-promoting effect in many tumors. However, the role of C1q in idiopathic pulmonary fibrosis and lung cancer still remain unclear.

Methods

We selected common differentially expressed genes in IPF and non-small cell lung cancer using datasets from GEO, and investigated common hub gene. The hub genes were validated in IPF by establishing mouse model of IP

SUBMITTER: Kou W 

PROVIDER: S-EPMC8790889 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature