Prenatal Exposure to Per- and Polyfluoroalkyl Substances and Facial Features at 5 Years of Age: A Study from the Danish National Birth Cohort.

ABSTRACT:

Background

Per- and polyfluoroalkyl substances (PFAS) are widespread persistent pollutants. Evidence regarding neurodevelopmental effects of PFAS have been mixed. The relation between PFAS exposure and anatomical markers that have been suggested to correlate with fetal brain development have not been studied.

Objectives

We investigated the association between prenatal PFAS exposures and three craniofacial features in children measured at 5 years of age.

Methods

Measures of palpebral fissure length (PFL), philtrum groove, and upper-lip thickness were generated from standardized digital facial photographs from 656 children in the Danish National Birth Cohort. PFL was classified into two groups (shorter; normal), and the philtrum (grooved; smooth; normal) and upper-lip (

SUBMITTER: Luo J 

PROVIDER: S-EPMC8791068 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature