Genome-wide Signatures of Early-Life Stress: Influence of Sex.

ABSTRACT: Both history of early-life stress (ELS) and female sex are associated with increased risk for depression. The complexity of how ELS interacts with brain development and sex to impart risk for multifaceted neuropsychiatric disorders is also unlikely to be understood by examining changes in single genes. Here, we review an emerging literature on genome-wide transcriptional and epigenetic signatures of ELS and the potential moderating influence of sex. We discuss evidence both that there are latent sex differences revealed by ELS and that ELS itself produces latent transcriptomic changes revealed by adult stress. In instances where there are broad similarities in global signatures of ELS among females and males, genes that contribute to these patterns are largely distinct based on sex. As thi

SUBMITTER: Parel ST 

PROVIDER: S-EPMC8791071 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature