Ontology highlight
ABSTRACT:
SUBMITTER: Luskin MR
PROVIDER: S-EPMC8791151 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Hematology. American Society of Hematology. Education Program 20211201 1
Unlike younger adults with acute lymphoblastic leukemia (ALL), older adults are rarely cured due to a combination of intrinsic disease resistance and treatment-related toxicities. Novel therapeutics such as inotuzumab ozogamicin, blinatumomab, venetoclax, and ABL kinase inhibitors have high activity in ALL and are well tolerated by older adults. Frontline treatment regimens for older adults using novel therapeutics with reduction or omission of conventional chemotherapy are being developed with ...[more]