M⁶A regulator-mediated methylation modification patterns and tumor immune microenvironment in sarcoma.

ABSTRACT:

Background

Studies have shown that the RNA N⁶-methyladenosine (m⁶A) modification patterns are extensively involved in the development of multiple tumors. However, the association between the m⁶A regulator expression patterns and the sarcoma tumor immune microenvironment (TIME) remains unclear.

Methods

We systematically evaluated the m⁶A regulator expression patterns in patients with sarcoma based on known 23 m⁶A regulators. Different m⁶A regulator expression patterns were analyzed using gene set variation analysis and a single-sample gene set enrichment analysis algorithm. According to the results of consensus clustering, we classified the patients into four different clusters. Next, we subjected the four clus

SUBMITTER: Li Z 

PROVIDER: S-EPMC8791212 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature