Alternative metabolic pathways and strategies to high-titre terpenoid production in Escherichia coli.

ABSTRACT: Covering: up to 2021Terpenoids are a diverse group of chemicals used in a wide range of industries. Microbial terpenoid production has the potential to displace traditional manufacturing of these compounds with renewable processes, but further titre improvements are needed to reach cost competitiveness. This review discusses strategies to increase terpenoid titres in Escherichia coli with a focus on alternative metabolic pathways. Alternative pathways can lead to improved titres by providing higher orthogonality to native metabolism that redirects carbon flux, by avoiding toxic intermediates, by bypassing highly-regulated or bottleneck steps, or by being shorter and thus more efficient and easier to manipulate. The canonical 2-C-methyl-D-erythritol 4-phosphate (MEP) and meval

SUBMITTER: Rinaldi MA 

PROVIDER: S-EPMC8791446 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature