The partition representation of enzymatic reaction networks and its application for searching bi-stable reaction systems.

ABSTRACT: The signal transduction system, which is known as a regulatory mechanism for biochemical reaction systems in the cell, has been the subject of intensive research in recent years, and its design methods have become necessary from the viewpoint of synthetic biology. We proposed the partition representation of enzymatic reaction networks consisting of post-translational modification reactions such as phosphorylation, which is an important basic component of signal transduction systems, and attempted to find enzymatic reaction networks with bistability to demonstrate the effectiveness of the proposed representation method. The partition modifiers can be naturally introduced into the partition representation of enzymatic reaction networks when applied to search. By randomly applying the partiti

SUBMITTER: Naka T 

PROVIDER: S-EPMC8791506 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature