Comparative transcriptome profiles of Schistosoma japonicum larval stages: Implications for parasite biology and host invasion.

ABSTRACT: Schistosoma japonicum is prevalent in Asia with a wide mammalian host range, which leads to highly harmful zoonotic parasitic diseases. Most previous transcriptomic studies have been performed on this parasite, but mainly focus on stages inside the mammalian host. Moreover, few larval transcriptomic data are available in public databases. Here we mapped the detailed transcriptome profiles of four S. japonicum larval stages including eggs, miracidia, sporocysts and cercariae, providing a comprehensive development picture outside of the mammalian host. By analyzing the stage-specific/enriched genes, we identified functional genes associated with the biological characteristic at each stage: e.g. we observed enrichment of genes necessary for DNA replication only in sporocysts, while those invo

SUBMITTER: Cheng S 

PROVIDER: S-EPMC8791509 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature