Ontology highlight
ABSTRACT:
SUBMITTER: Simoes ML
PROVIDER: S-EPMC8791531 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Simões Maria L ML Dong Yuemei Y Mlambo Godfree G Dimopoulos George G
PLoS biology 20220113 1
Anopheles gambiae melanization-based refractoriness to the human malaria parasite Plasmodium falciparum has rarely been observed in either laboratory or natural conditions, in contrast to the rodent model malaria parasite Plasmodium berghei that can become completely melanized by a TEP1 complement-like system-dependent mechanism. Multiple studies have shown that the rodent parasite evades this defense by recruiting the C-type lectins CTL4 and CTLMA2, while permissiveness to the human malaria par ...[more]