Benzo[a]pyrene (BaP) metabolites predominant in human plasma following escalating oral micro-dosing with [¹⁴C]-BaP.

ABSTRACT: Benzo[a]pyrene (BaP) is formed by incomplete combustion of organic materials (petroleum, coal, tobacco, etc.). BaP is designated by the International Agency for Research on Cancer as a group 1 known human carcinogen; a classification supported by numerous studies in preclinical models and epidemiology studies of exposed populations. Risk assessment relies on toxicokinetic and cancer studies in rodents at doses 5-6 orders of magnitude greater than average human uptake. Using a dose-response design at environmentally relevant concentrations, this study follows uptake, metabolism, and elimination of [¹⁴C]-BaP in human plasma by employing UPLC - accelerator mass spectrometry (UPLC-AMS). Volunteers were administered 25, 50, 100, and 250 ng (2.7-27 nCi) of [¹⁴C]-BaP (with i

SUBMITTER: Vermillion Maier ML 

PROVIDER: S-EPMC8791557 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature